GGN40 Skullsmasher
The GGN40 Skullsmasher is a 400mm anti-material rifle designed by Dr. Seuss during WWII.
Improving upon depleted uranium, this rifle fires antimatter rounds. Thus it has unlimited range as antimatter cannot be stopped by anything, be it gravity or 500-foot thick concrete walls. When a round is fired, it simply goes on in a straight line through the universe forever.